Topological pressure-temperature state diagram of the crystalline dimorphism of 2,4,6-trinitrotoluene
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چکیده
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Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide.
Understanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however up to now its stability behavior was not clear, as few thermodynamic data were available. Therefore, calorimetric melting data have been obtained, which were found to be TI...
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ژورنال
عنوان ژورنال: Fluid Phase Equilibria
سال: 2020
ISSN: 0378-3812
DOI: 10.1016/j.fluid.2019.112395